Report Code : CVMI2603252601422 | Published Date : March 30, 2025
1 | Market Overview
The global checkpoint inhibitors market is experiencing rapid growth, fueled by the increasing prevalence of cancer and rising demand for immunotherapy treatments. Checkpoint inhibitors work by blocking immune checkpoints such as PD-1, PD-L1, and CTLA-4, thus enabling the immune system to attack cancer cells more effectively.
The expansion of the checkpoint inhibitors market is driven by rising approvals of new indications, growing oncology research, and ongoing investment in combination therapies. Advances in biomarker-driven patient selection and precision medicine are additionally accelerating the market's growth.
2 | Market Size and Forecast
Year |
Market Value (USD Billion) |
Notes |
2019 |
23.5 |
Historical benchmark |
2024 |
41.9 |
Five-year CAGR 12.1% |
2031 |
98.6 |
Seven-year CAGR 12.9% |
The market is projected to more than double by 2031, propelled by wider cancer indication approvals and increased adoption of immunotherapies globally.
3 | Key Market Drivers
- Rising Cancer Incidence Worldwide.
- Increased Adoption of Immunotherapy as First-Line Treatment.
- Expanding Pipeline for Multiple Cancer Types.
- Biomarker-Driven Patient Selection and Precision Medicine.
- Favorable Regulatory Approvals for New Indications.
4 | Market Challenges
- High Treatment Costs.
- Immune-Related Adverse Events (irAEs).
- Variable Response Rates Among Patients.
- Regulatory Complexities in Emerging Markets.
5 | Competitive Landscape
The checkpoint inhibitors market is highly consolidated, dominated by leading pharmaceutical companies with blockbuster oncology drugs.
Market Share Estimates (2024):
Company |
Estimated Market Share |
Key Products |
Bristol-Myers Squibb |
24% |
Opdivo® (nivolumab), Yervoy® (ipilimumab) |
Merck & Co. |
21% |
Keytruda® (pembrolizumab) |
Roche (Genentech) |
16% |
Tecentriq® (atezolizumab) |
AstraZeneca |
12% |
Imfinzi® (durvalumab) |
Others (Pfizer, Novartis, Gilead, BeiGene) |
27% |
Novel and regional checkpoint inhibitors |
6 | Market Segmentation
By Drug Class:
- PD-1 Inhibitors
- PD-L1 Inhibitors
- CTLA-4 Inhibitors
- Others (LAG-3, TIGIT, emerging targets)
By Application:
- Lung Cancer
- Melanoma
- Renal Cell Carcinoma
- Bladder Cancer
- Head and Neck Cancer
- Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
By End User:
- Hospitals
- Oncology Centers
- Research Institutes
- Specialty Clinics
By Region:
- North America
- Europe
- Asia-Pacific
- Latin America
- Middle East & Africa
7 | Strategic Outlook
The checkpoint inhibitors market will continue evolving with next-generation checkpoint targets (e.g., LAG-3, TIM-3, TIGIT), biomarker-driven treatments, AI-powered drug discovery, and expansion into early-stage cancers and adjuvant therapy settings.
Reasons To Buy

Scope

Key Players
- Bristol Myers Squibb
- Merck & Co.
- Roche
- AstraZeneca
- Pfizer
- Novartis
- Regeneron
- Gilead Sciences
Global Checkpoint Inhibitors Market Report
- 1. Global Checkpoint Inhibitors Market Research Report
- 1.1 Study Objectives
- 1.2 Global Checkpoint Inhibitors Market - Overview
- 1.3 Reason to Read This Report
- 1.4 Methodology and Forecast Analysis
- 2. Global Checkpoint Inhibitors Market Research Report - Preface
- 2.1 Global Checkpoint Inhibitors Market Research Report – Detailed Scope and Definitions
- 2.1.1 By Drug Class
- 2.1.2 By Application
- 2.1.3 By End User
- 2.1.4 By Region
- 2.1 Global Checkpoint Inhibitors Market Research Report – Detailed Scope and Definitions
- 3. Global Checkpoint Inhibitors Market Dynamics
- 3.1. Drivers - Macro-Economic Based, Supply Side, and Demand Side Drivers
- 3.2. Restraints – By Drug Class, By Application, By End User, By Country
- 3.3. Opportunities – By Drug Class, By Application, By End User, By Country
- 3.4. Trends – By Drug Class, By Application, By End User, By Country
- 3.5. PEST Analysis
- 3.6. Porters Five Rule Analysis
- 3.7. Company’s Share Analysis (CSA) by Region or By Country
- 3.8. Global Checkpoint Inhibitors Market Research Report – DROTs Impact Analysis
-
- 4. Global Checkpoint Inhibitors Market Research Report, Historic Data 2019 - 2023 and Forecast Analysis Data 2024 - 2031
- 4.1. Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 4.2. Annual Market Trend Assessment – Year-on-Year (YoY) Growth Analysis (%)
- 4.3. Incremental Market Value/Volume Opportunity between 2019 - 2023 and 2024 - 2031
- 4.4. Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 5. Global Checkpoint Inhibitors Market, By Drug Class, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
- 5.1 PD-1 Inhibitors
- 5.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 5.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 5.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 5.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 5.2 PD-L1 Inhibitors
- 5.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 5.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 5.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 5.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 5.3 CTLA-4 Inhibitors
- 5.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 5.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 5.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 5.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 5.4 Others (LAG-3, TIGIT, emerging targets)
- 5.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 5.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 5.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 5.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.1 Lung Cancer
- 6.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.2 Melanoma
- 6.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.3 Renal Cell Carcinoma
- 6.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.4 Bladder Cancer
- 6.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.5 Head and Neck Cancer
- 6.5.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.5.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.5.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.5.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 6.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 6.6.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 6.6.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 6.6.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 6.6.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 7.1 Hospitals
- 7.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 7.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 7.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 7.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 7.2 Oncology Centers
- 7.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 7.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 7.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 7.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 7.3 Research Institutes
- 7.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 7.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 7.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 7.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 7.4 Specialty Clinics
- 7.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 7.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 7.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 7.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8. Global Checkpoint Inhibitors Market Forecast, By Region, 2019 - 2023 and 2024 - 2031 (Market Value, In USD Mn)
- 8.1 North America
- 8.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 8.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 8.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 8.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 8.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 8.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 8.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 8.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 8.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 8.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 8.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 8.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 8.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8.5.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
- 8.5.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
- 8.5.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
- 8.5.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
- 8.1 North America
- 9. North America Global Checkpoint Inhibitors Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
- 9.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 9.1.1 PD-1 Inhibitors
- 9.1.2 PD-L1 Inhibitors
- 9.1.3 CTLA-4 Inhibitors
- 9.1.4 Others (LAG-3, TIGIT, emerging targets)
- 9.2.1 Lung Cancer
- 9.2.2 Melanoma
- 9.2.3 Renal Cell Carcinoma
- 9.2.4 Bladder Cancer
- 9.2.5 Head and Neck Cancer
- 9.2.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 9.3.1 Hospitals
- 9.3.2 Oncology Centers
- 9.3.3 Research Institutes
- 9.3.4 Specialty Clinics
- 9.4.1 United States
- 9.4.2 Canada
- 9.5 North America Global Checkpoint Inhibitors Market – Opportunity Analysis Index, By Drug Class, By Application, By End User, and Country, 2024 - 2031
- 9.6 Regional Trends Analysis
- 9.7 North America Global Checkpoint Inhibitors Market Research Report - Company Profiles
- 9.7.1 Company 1 (United States)
- 9.7.2 Company 2 (Canada)
- 9.7.3 Company 3 (Canada)
- 10.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 10.1.1 PD-1 Inhibitors
- 10.1.2 PD-L1 Inhibitors
- 10.1.3 CTLA-4 Inhibitors
- 10.1.4 Others (LAG-3, TIGIT, emerging targets)
- 10.2.1 Lung Cancer
- 10.2.2 Melanoma
- 10.2.3 Renal Cell Carcinoma
- 10.2.4 Bladder Cancer
- 10.2.5 Head and Neck Cancer
- 10.2.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 10.3.1 Hospitals
- 10.3.2 Oncology Centers
- 10.3.3 Research Institutes
- 10.3.4 Specialty Clinics
- 10.4.1 Germany
- 10.4.2 United Kingdom
- 10.4.3 France
- 10.4.4 Spain
- 10.4.5 Italy
- 10.4.6 Russia
- 10.4.7 Netherlands and Rest of Europe
- 10.5 Europe Global Checkpoint Inhibitors Market – Opportunity Analysis Index, By Drug Class, By Application, By End User, and Country, 2024 - 2031
- 10.6 Regional Trends Analysis
- 10.7 Europe Global Checkpoint Inhibitors Market Research Report - Company Profiles
- 10.7.1 Company 1 (Germany)
- 10.7.2 Company 2 (United Kingdom)
- 10.7.3 Company 3 (United Kingdom)
- 11.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 11.1.1 PD-1 Inhibitors
- 11.1.2 PD-L1 Inhibitors
- 11.1.3 CTLA-4 Inhibitors
- 11.1.4 Others (LAG-3, TIGIT, emerging targets)
- 11.2.1 Lung Cancer
- 11.2.2 Melanoma
- 11.2.3 Renal Cell Carcinoma
- 11.2.4 Bladder Cancer
- 11.2.5 Head and Neck Cancer
- 11.2.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 11.3.1 Hospitals
- 11.3.2 Oncology Centers
- 11.3.3 Research Institutes
- 11.3.4 Specialty Clinics
- 11.4.1 China
- 11.4.2 Japan
- 11.4.3 India
- 11.4.4 South Korea
- 11.4.5 Australia & New Zealand
- 11.4.6 ASEAN
- 11.4.7 Rest of Asia-Pacific
- 11.5 Asia-Pacific Global Checkpoint Inhibitors Market – Opportunity Analysis Index, By Drug Class, By Application, By End User, and Country, 2024 - 2031
- 11.6 Regional Trends Analysis
- 11.7 Asia-Pacific Global Checkpoint Inhibitors Market Research Report - Company Profiles
- 11.7.1 Company 1 (China)
- 11.7.2 Company 2 (Japan)
- 11.7.3 Company 3 (Japan)
- 12.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 12.1.1 PD-1 Inhibitors
- 12.1.2 PD-L1 Inhibitors
- 12.1.3 CTLA-4 Inhibitors
- 12.1.4 Others (LAG-3, TIGIT, emerging targets)
- 12.2.1 Lung Cancer
- 12.2.2 Melanoma
- 12.2.3 Renal Cell Carcinoma
- 12.2.4 Bladder Cancer
- 12.2.5 Head and Neck Cancer
- 12.2.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 12.3.1 Hospitals
- 12.3.2 Oncology Centers
- 12.3.3 Research Institutes
- 12.3.4 Specialty Clinics
- 12.4.1 Brazil
- 12.4.2 Mexico
- 12.4.3 Argentina
- 12.4.4 Peru
- 12.4.5 Colombia
- 12.4.6 Rest of Latin America
- 12.5 Latin America Global Checkpoint Inhibitors Market – Opportunity Analysis Index, By Drug Class, By Application, By End User, and Country, 2024 - 2031
- 12.6 Regional Trends Analysis
- 12.7 Latin America Global Checkpoint Inhibitors Market Research Report - Company Profiles
- 12.7.1 Company 1 (Brazil)
- 12.7.2 Company 2 (Mexico)
- 12.7.3 Company 3 (Mexico)
- 13.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 13.1.1 PD-1 Inhibitors
- 13.1.2 PD-L1 Inhibitors
- 13.1.3 CTLA-4 Inhibitors
- 13.1.4 Others (LAG-3, TIGIT, emerging targets)
- 13.2.1 Lung Cancer
- 13.2.2 Melanoma
- 13.2.3 Renal Cell Carcinoma
- 13.2.4 Bladder Cancer
- 13.2.5 Head and Neck Cancer
- 13.2.6 Others (Triple-Negative Breast Cancer, Gastrointestinal Cancers)
- 13.3.1 Hospitals
- 13.3.2 Oncology Centers
- 13.3.3 Research Institutes
- 13.3.4 Specialty Clinics
- 13.4.1 Saudi Arabia
- 13.4.2 UAE
- 13.4.3 Qatar
- 13.4.4 Egypt
- 13.4.5 Israel
- 13.4.6 Rest of Middle East and Africa
- 13.5 Middle East and Africa Global Checkpoint Inhibitors Market – Opportunity Analysis Index, By Drug Class, By Application, By End User, and Country, 2024 - 2031
- 13.6 Regional Trends Analysis
- 13.7 Middle East and Africa Global Checkpoint Inhibitors Market Research Report - Company Profiles
- 13.7.1 Company 1 (Saudi Arabia)
- 13.7.2 Company 2 (UAE)
- 13.7.3 Company 3 (UAE)
- 14.1 Strategic Dashboard of Top Market Players
- 14.2 Company Profiles (Introduction, Financial Assessments, Portfolio of Offerings, Milestones and Achievements, Strategic Initiative, and SWOT Analysis)
- 14.2.1 Bristol Myers Squibb
- 14.2.2 Merck & Co.
- 14.2.3 Roche
- 14.2.4 AstraZeneca
- 14.2.5 Pfizer
- 14.2.6 Novartis
- 14.2.7 Regeneron
- 14.2.8 Gilead Sciences
- 9.1 By Drug Class Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
- 15. Data Collection Method and Research Approach
- 16. Principal Presumptions and Acronyms