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Forecast Period

2024–2031

Base years: 2019–2023

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The Global Liver Preservation Systems Market is undergoing a technological renaissance, driven by critical organ shortages, advancements in perfusion technology, and a growing demand for transplantable organs. Valued at USD 230 million in 2023, the market is projected to grow at a CAGR of 9.8%, reaching USD 480 million by 2031. This comprehensive analysis examines the paradigm shift from static cold storage to dynamic preservation methods that significantly improve transplant outcomes and expand the donor pool.

Three key trends are reshaping the market: the validation of normothermic perfusion systems, the development of organ repair technologies during preservation, and the use of AI-driven viability assessment tools. The report highlights comparisons of preservation techniques, clinical outcomes, and the economic effects of extended preservation times. It also focuses on the growing use of marginal donor organs and the expedited regulatory pathways for new preservation systems.

2. Market Overview

2.1 Market Definition & Scope

Liver preservation systems encompass technologies that maintain organ viability between procurement and transplantation:

Static Cold Storage (SCS) (XX% market share)
- Traditional ice storage
- Hypothermic solutions
Machine Perfusion Systems (XX%)
- Hypothermic perfusion
- Normothermic perfusion
- Subnormothermic perfusion

Key application segments:

Transplant Centers (XX%)
Organ Procurement Organizations (25%)
Research Institutions (XX%)

2.2 Market Size & Forecast (2023-2031)

2023 Market Size: USD 230 Million
2031 Projected Size: USD 480 Million
CAGR: 9.8%
Annual Liver Transplants: 40,000 (2023) → 65,000 (2031)

2.3 Key Market Segments

By Preservation Technique:

Static Cold Storage (XX% share)
- University of Wisconsin solution (XX%)
- Histidine-Tryptophan-Ketoglutarate (HTK) (XX%)
- Other solutions (20%)
Machine Perfusion (XX%)
- Hypothermic (50%)
- Normothermic (XX%)
- Subnormothermic (XX%)

By Organ Quality:

Standard Criteria Donors (XX%)
Extended Criteria Donors (XX%)

By Region:

North America (45%)
Europe (XX%)
Asia-Pacific (XX%)
Rest of World (XX%)

3. Market Dynamics

3.1 Market Drivers

1. Critical Organ Shortage

20 patients die daily awaiting liver transplants (U.S.)
Extended criteria donors now 40% of transplants

2. Superior Clinical Outcomes

50% lower early allograft dysfunction
30% improved 1-year graft survival with perfusion

3. Regulatory Support

FDA Breakthrough Device designations
EU MDR creating standardized protocols

4. Technological Convergence

Ex vivo liver repair during perfusion
AI viability scoring systems

3.2 Market Challenges

1. High System Costs

USD 250,000 average perfusion device cost
Limited reimbursement pathways

2. Operational Complexity

Specialized training requirements
Logistical challenges in transport

3. Evidence Generation

Long-term outcome data still emerging
Comparative effectiveness studies needed

3.3 Market Trends

1. Portable Perfusion Systems

Compact designs for air transport
Battery-powered operation

2. Organ Repair Technologies

Stem cell infusion during perfusion
Gene therapy delivery

3. Viability Biomarkers

Real-time metabolite monitoring
Machine learning prediction algorithms

4. Competitive Landscape

4.1 Market Share Analysis

Company	Market Share	Key Products	Strategic Focus
TransMedics	30%	OCS Liver System	Normothermic leadership
OrganOx	25%	metra Device	Clinical evidence generation
Bridge to Life	20%	VitaSmart System	Hypothermic solutions
XVIVO Perfusion	15%	XPS System	Portable technology
Paragonix	10%	LIVERguard	Cold storage innovation

4.2 Emerging Players

Organ Assist: Modular perfusion (40% growth)
Liver4Life: Ex vivo repair technology
Preservation Solutions: Next-gen cold storage

4.3 Recent Developments (2024)

TransMedics FDA approval for DCD liver preservation
OrganOx published 5-year outcome data
XVIVO launched next-gen portable system

5. Regional Analysis

5.1 North America (XX%)

US dominates with 80% regional share
Canada implementing national perfusion protocols

5.2 Europe (XX%)

UK/Germany leading clinical adoption
EU funding for preservation research

5.3 Asia-Pacific (15%)

China fastest-growing at 12% CAGR
India expanding transplant infrastructure

6. Future Outlook

6.1 Short-Term Projections (2025)

50% market share for perfusion systems
First commercial liver repair systems

6.2 Medium-Term Outlook (2027)

Standard of care for marginal organs
Automated viability assessment

6.3 Long-Term Forecast (2031)

7-day preservation becoming possible
Widespread adoption of repair technologies

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Key Players

XVIVO Perfusion AB
OrganOx Limited
TransMedics Inc.
Bridge to Life Ltd.
Paragonix Technologies Inc.

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Global Liver Preservation Systems Market Report

1. Global Liver Preservation Systems Market Research Report
1. 1.1 Study Objectives
2. 1.2 Global Liver Preservation Systems Market - Overview
3. 1.3 Reason to Read This Report
4. 1.4 Methodology and Forecast Analysis
2. Global Liver Preservation Systems Market Research Report - Preface
1. 2.1 Global Liver Preservation Systems Market Research Report – Detailed Scope and Definitions
  1. 2.1.1 By Type
  2. 2.1.2 By Application
  3. 2.1.3 By End-user
  4. 2.1.4 By Region
3. Global Liver Preservation Systems Market Dynamics
1. 3.1. Drivers - Macro-Economic Based, Supply Side, and Demand Side Drivers
2. 3.2. Restraints – By Type, By Application, By End-user, By Country
3. 3.3. Opportunities – By Type, By Application, By End-user, By Country
4. 3.4. Trends – By Type, By Application, By End-user, By Country
5. 3.5. PEST Analysis
6. 3.6. Porters Five Rule Analysis
7. 3.7. Company’s Share Analysis (CSA) by Region or By Country
8. 3.8. Global Liver Preservation Systems Market Research Report – DROTs Impact Analysis
4. Global Liver Preservation Systems Market Research Report, Historic Data 2019 - 2023 and Forecast Analysis Data 2024 - 2031
1. 4.1. Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
2. 4.2. Annual Market Trend Assessment – Year-on-Year (YoY) Growth Analysis (%)
3. 4.3. Incremental Market Value/Volume Opportunity between 2019 - 2023 and 2024 - 2031
4. 4.4. Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
5. Global Liver Preservation Systems Market, By Type, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 5.1 Static Cold Storage
  1. 5.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 5.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 5.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 5.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
2. 5.2 Machine Perfusion
  1. 5.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 5.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 5.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 5.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
6. Global Liver Preservation Systems Market, By Application, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 6.1 Transplantation
  1. 6.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 6.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 6.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 6.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
2. 6.2 Research
  1. 6.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 6.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 6.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 6.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
7. Global Liver Preservation Systems Market, By End-user, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 7.1 Hospitals
  1. 7.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 7.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 7.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 7.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
2. 7.2 Research Institutions
  1. 7.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 7.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 7.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 7.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
3. 7.3 Organ Procurement Organizations.
  1. 7.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 7.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 7.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 7.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
8. Global Liver Preservation Systems Market Forecast, By Region, 2019 - 2023 and 2024 - 2031 (Market Value, In USD Mn)
1. 8.1 North America
  1. 8.1.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 8.1.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 8.1.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 8.1.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
2. 8.2 Europe
  1. 8.2.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 8.2.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 8.2.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 8.2.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
3. 8.3 Asia-Pacific
  1. 8.3.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 8.3.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 8.3.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 8.3.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
4. 8.4 Latin America
  1. 8.4.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 8.4.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 8.4.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 8.4.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
5. 8.5 Middle East & Africa
  1. 8.5.1 Market Performance Review & Future Outlook: Assessing 2019 - 2023 and Predicting 2024 - 2031 Trends (USD Millions)
  2. 8.5.2 Annual Market Trend Assessment – Yearly Growth Observation (Y-O-Y)(%)
  3. 8.5.3 Incremental Market Value/Volume Opportunity between 2019 - 2023 and From 2024 to 2031
  4. 8.5.4 Market Shares Analysis in Years - 2019, 2023, 2024 and 2031
6. 8.6 Global Liver Preservation Systems Market - Opportunity Analysis Index, By Type, By Application, By End-user, and Region, 2024 - 2031
9. North America Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 9.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 9.1.1 Static Cold Storage
  2. 9.1.2 Machine Perfusion
  9.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 9.2.1 Transplantation
  2. 9.2.2 Research
  9.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 9.3.1 Hospitals
  2. 9.3.2 Research Institutions
  3. 9.3.3 Organ Procurement Organizations.
  9.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 9.4.1 United States
  2. 9.4.2 Canada
  9.5 North America Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
  9.6 Regional Trends Analysis
  9.7 North America Global Liver Preservation Systems Market Research Report - Company Profiles
  1. 9.7.1 Company 1 (United States)
  2. 9.7.2 Company 2 (Canada)
  3. 9.7.3 Company 3 (Canada)
10. Europe Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 10.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 10.1.1 Static Cold Storage
  2. 10.1.2 Machine Perfusion
  10.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 10.2.1 Transplantation
  2. 10.2.2 Research
  10.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 10.3.1 Hospitals
  2. 10.3.2 Research Institutions
  3. 10.3.3 Organ Procurement Organizations.
  10.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 10.4.1 Germany
  2. 10.4.2 United Kingdom
  3. 10.4.3 France
  4. 10.4.4 Spain
  5. 10.4.5 Italy
  6. 10.4.6 Russia
  7. 10.4.7 Netherlands
  8. 10.4.8 Poland
  9. 10.4.9 Rest of Europe
  10.5 Europe Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
  10.6 Regional Trends Analysis
  10.7 Europe Global Liver Preservation Systems Market Research Report - Company Profiles
  1. 10.7.1 Company 1 (Germany)
  2. 10.7.2 Company 2 (United Kingdom)
  3. 10.7.3 Company 3 (United Kingdom)
11. Asia-Pacific Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 11.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 11.1.1 Static Cold Storage
  2. 11.1.2 Machine Perfusion
  11.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 11.2.1 Transplantation
  2. 11.2.2 Research
  11.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 11.3.1 Hospitals
  2. 11.3.2 Research Institutions
  3. 11.3.3 Organ Procurement Organizations.
  11.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 11.4.1 China
  2. 11.4.2 Japan
  3. 11.4.3 India
  4. 11.4.4 South Korea
  5. 11.4.5 Australia & NZ
  6. 11.4.6 ASEAN
  7. 11.4.7 Rest of Asia-Pacific
  11.5 Asia-Pacific Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
  11.6 Regional Trends Analysis
  11.7 Asia-Pacific Global Liver Preservation Systems Market Research Report - Company Profiles
  1. 11.7.1 Company 1 (China)
  2. 11.7.2 Company 2 (Japan)
  3. 11.7.3 Company 3 (Japan)
12. Latin America Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 12.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 12.1.1 Static Cold Storage
  2. 12.1.2 Machine Perfusion
  12.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 12.2.1 Transplantation
  2. 12.2.2 Research
  12.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 12.3.1 Hospitals
  2. 12.3.2 Research Institutions
  3. 12.3.3 Organ Procurement Organizations.
  12.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 12.4.1 Brazil
  2. 12.4.2 Mexico
  3. 12.4.3 Argentina
  4. 12.4.4 Peru
  5. 12.4.5 Colombia
  6. 12.4.6 Rest of Latin America
  12.5 Latin America Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
  12.6 Regional Trends Analysis
  12.7 Latin America Global Liver Preservation Systems Market Research Report - Company Profiles
  1. 12.7.1 Company 1 (Brazil)
  2. 12.7.2 Company 2 (Mexico)
  3. 12.7.3 Company 3 (Mexico)
13. Middle East & Africa Global Liver Preservation Systems Market Analysis, 2019 - 2023 and Forecast, 2024 - 2031 (Market Value, In USD Mn)
1. 13.1 By Type Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 13.1.1 Static Cold Storage
  2. 13.1.2 Machine Perfusion
  13.2 By Application Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 13.2.1 Transplantation
  2. 13.2.2 Research
  13.3 By End-user Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 13.3.1 Hospitals
  2. 13.3.2 Research Institutions
  3. 13.3.3 Organ Procurement Organizations.
  13.4 Country Analysis 2019 - 2023 and Forecast, 2024 - 2031 by Market Assessment (USD Mn), Yearly Growth Rate (%), and Market Presence (%)
  1. 13.4.1 Saudi Arabia
  2. 13.4.2 UAE
  3. 13.4.3 South Africa
  4. 13.4.4 Egypt
  5. 13.4.5 Israel
  6. 13.4.6 Rest of Middle East and Africa
  13.5 Middle East & Africa Global Liver Preservation Systems Market – Opportunity Analysis Index, By Type, By Application, By End-user, and Country, 2024 - 2031
  13.6 Regional Trends Analysis
  13.7 Middle East & Africa Global Liver Preservation Systems Market Research Report - Company Profiles
  1. 13.7.1 Company 1 (Saudi Arabia)
  2. 13.7.2 Company 2 (UAE)
  3. 13.7.3 Company 3 (UAE)
14. Competition Landscape
1. 14.1 Strategic Dashboard of Top Market Players
  14.2 Company Profiles (Introduction, Financial Assessments, Portfolio of Offerings, Milestones and Achievements, Strategic Initiative, and SWOT Analysis)
  1. 14.2.1 XVIVO Perfusion AB
  2. 14.2.2 OrganOx Limited
  3. 14.2.3 TransMedics Inc.
  4. 14.2.4 Bridge to Life Ltd.
  5. 14.2.5 Paragonix Technologies Inc.
15. Data Collection Method and Research Approach
16. Principal Presumptions and Acronyms

Methodology & Credibility

Built for enterprise decisions, not vanity metrics.

Triangulated Sizing

Bottom-up, top-down, and peer benchmarks reconciled by analysts.

Primary + Secondary Research

Executive interviews combined with validated public and paid sources.

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Base, bull and bear cases to stress-test strategic moves.

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Global Liver Preservation Systems Market Research Report, Historic Data 2019 - 2023 and Forecast Analysis 2024 - 2031

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Global Liver Preservation Systems Market Report

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